Allergic conditions such as asthma involve histamine release and the degranulation of mast cells. This study evaluated the anti-histaminic activity of Moringa oleifera seed extract to validate its traditional use for respiratory and allergic complaints.
Ethanolic seed extract (500 mg/kg) was tested in Wistar rats using horse-serum and triple-antigen-induced anaphylaxis models, alongside a phytochemical analysis of the extract.
Key findings
- The seed extract significantly decreased histamine secretion and mast-cell degranulation in the rats.
- Phytochemical screening found steroid saponins, alkaloids, flavonoids and glycosides.
- The glycoside-saponin fraction is linked to the mast-cell-stabilising, anti-histaminic effect.
Why it matters for MORIFA: Respiratory and allergy support is a meaningful wellness niche. Evidence that moringa seed has anti-histaminic action adds another health angle for our seed products.
Caveat: an animal study validating a traditional use; this is research information, not medical advice.
Summary of: “Antihistaminic activity of Moringa oleifera seed extract.” Summarised by MORIFA; full paper via the PDF link above.